来自法国分离出的肠杆菌科细菌中的CTX-M-1、CTX-M-3和CTX-M-14β-内酰胺酶
CTX-M-1, CTX-M-3, and CTX-M-14 beta-lactamases from Enterobacteriaceae isolated in France.
作者信息
Dutour C, Bonnet R, Marchandin H, Boyer M, Chanal C, Sirot D, Sirot J
机构信息
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, France.
出版信息
Antimicrob Agents Chemother. 2002 Feb;46(2):534-7. doi: 10.1128/AAC.46.2.534-537.2002.
Abstract
Six clinical CTX-M-producing isolates of the family Enterobacteriaceae were detected between 1999 and 2000 in different French hospitals. Two strains produced CTX-M-1 and CTX-M-3 and four strains produced CTX-M-14, a mutant Ala-231-->Val of CTX-M-9. A putative transposable element, ISEcp-1, was located 43 bp upstream of all the bla(CTX-M) genes. Two CTX-M-14-encoding plasmids exhibited similar restriction patterns. The CTX-M-1- and CTX-M-3-encoding plasmids were related to the CTX-M-1- and CTX-M-3-encoding plasmids previously reported in 1990 in France and in 1998 in Poland, respectively.
摘要
1999年至2000年期间，在法国不同医院检测到6株产CTX-M的肠杆菌科临床分离株。其中2株产生CTX-M-1和CTX-M-3，4株产生CTX-M-14，后者是CTX-M-9的Ala-231→Val突变体。一个假定的转座元件ISEcp-1位于所有bla(CTX-M)基因上游43 bp处。两个编码CTX-M-14的质粒表现出相似的限制性酶切图谱。编码CTX-M-1和CTX-M-3的质粒分别与1990年在法国和1998年在波兰报道的编码CTX-M-1和CTX-M-3的质粒相关。
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