化脓性链球菌双组分反应调节因子在Mga及Mga调控的毒力基因emm的时序控制中的作用
Role of Streptococcus pyogenes two-component response regulators in the temporal control of Mga and the Mga-regulated virulence gene emm.
作者信息
Ribardo Deborah A, Lambert Thomas J, McIver Kevin S
机构信息
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9048, USA.
出版信息
Infect Immun. 2004 Jun;72(6):3668-73. doi: 10.1128/IAI.72.6.3668-3673.2004.
Abstract
We examined the role of Streptococcus pyogenes two-component response regulators (SptR) in expression of Mga and the Mga-regulated gene emm. Both serotype M6 and serotype M1 mutants in 12 of the 13 identified sptR genes exhibited levels of emm transcripts and Mga protein comparable to those of the wild type during exponential and stationary phases of growth. Thus, temporal control of these virulence genes does not require Spt response regulators.
摘要
我们研究了化脓性链球菌双组分反应调节因子（SptR）在Mga和Mga调控基因emm表达中的作用。在13个已鉴定的sptR基因中的12个基因中，血清型M6和血清型M1突变体在生长的指数期和稳定期的emm转录本水平和Mga蛋白水平与野生型相当。因此，这些毒力基因的时序控制不需要Spt反应调节因子。
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