一种来自毛茶的新型3,4-断羽扇豆烷衍生物。

A new 3,4-seco-lupane derivative from Lasianthus gardneri.

作者信息

Dallavalle Sabrina, Jayasinghe Lalith, Kumarihamy B M M, Merlini Lucio, Musso Loana, Scaglioni Leonardo

机构信息

Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Via Celoria 2, 20133 Milano, Italy.

出版信息

J Nat Prod. 2004 May;67(5):911-3. doi: 10.1021/np030374g.

DOI:10.1021/np030374g

PMID:15165165

Abstract

A new seco-ring A lupane triterpene derivative (1), along with lupenone, lupeol, beta-sitosterol, ursolic acid, and stigmasterol 3-O-beta-d-glucoside, were isolated from a methanol extract of mature stems of Lasianthus gardneri, a shrub from the family Rubiaceae growing in Sri Lanka. The structure and stereochemistry of the new compound were determined using a combination of (13)C and (1)H homo- and heteronuclear 2D NMR experiments and from mass spectral data. The structure of 1 was confirmed by partial synthesis from lupeol.

摘要

从茜草科灌木拉氏粗叶木（Lasianthus gardneri）成熟茎的甲醇提取物中分离出一种新的裂环A羽扇烷三萜衍生物（1），以及羽扇酮、羽扇豆醇、β-谷甾醇、熊果酸和豆甾醇3-O-β-D-葡萄糖苷。该新化合物的结构和立体化学通过13C和1H同核和异核二维核磁共振实验以及质谱数据相结合的方法确定。化合物1的结构通过从羽扇豆醇进行部分合成得以确证。该灌木生长于斯里兰卡。