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神经母细胞瘤SH-SY5Y细胞毒性、抗淀粉样生成活性及茜草科植物的环氧化酶抑制作用

Neuroblastoma SH-SY5Y cytotoxicity, anti-amyloidogenic activity and cyclooxygenase inhibition of (Rubiaceae).

作者信息

Tan Mario A, Lagamayo Mark Wilson D, Alejandro Grecebio Jonathan D, An Seong Soo A

机构信息

1The Graduate School, University of Santo Tomas, Manila, Philippines.

2College of Science, University of Santo Tomas, Manila, Philippines.

出版信息

3 Biotech. 2020 Apr;10(4):152. doi: 10.1007/s13205-020-2145-2. Epub 2020 Mar 3.

DOI:10.1007/s13205-020-2145-2
PMID:32181114
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7054575/
Abstract

The anti-amyloidogenic potential and cyclooxygenase anti-inflammatory activity of extracts were evaluated. The MeOH extract (LTM) and chloroform extract (LTC) exhibited significant cytotoxic inhibition against the neuroblastoma SH-SY5Y cell with an IC of 17.52 μg/mL and 12.28 μg/mL, respectively. Thioflavin T assay indicated the LTC extract inhibition (70.56% at 50 μg/mL) to be statistically comparable ( < 0.05) to the positive control. Cyclooxygenase inhibition against COX-1 and COX-2 enzymes gave IC values for the LTM extract to be 18.20 and 29.60 µg/mL, respectively; while, the LTC extract showed 4.11 and 2.78 µg/mL, respectively. LC-MS of the LTM extract identified 22 putative compounds, which may prove to be pharmacologically relevant. This study has provided potential insights into the utilization of to develop safer plant-based agents for anti-inflammatory or neurodegenerative diseases.

摘要

对提取物的抗淀粉样蛋白生成潜力和环氧化酶抗炎活性进行了评估。甲醇提取物（LTM）和氯仿提取物（LTC）对神经母细胞瘤SH-SY5Y细胞表现出显著的细胞毒性抑制作用，IC50分别为17.52μg/mL和12.28μg/mL。硫黄素T测定表明，LTC提取物在50μg/mL时的抑制率（70.56%）与阳性对照在统计学上具有可比性（P<0.05）。对COX-1和COX-2酶的环氧化酶抑制作用显示，LTM提取物的IC50值分别为18.20和29.60μg/mL；而LTC提取物的IC50值分别为4.11和2.78μg/mL。LTM提取物的液相色谱-质谱分析鉴定出22种推定化合物，这些化合物可能具有药理相关性。本研究为利用[提取物名称未给出]开发更安全的用于抗炎或神经退行性疾病的植物源药物提供了潜在的见解。