可复制且具有重组活性的RNA
Replicable and recombinogenic RNAs.
作者信息
Chetverin Alexander B
机构信息
Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow, Russia.
出版信息
FEBS Lett. 2004 Jun 1;567(1):35-41. doi: 10.1016/j.febslet.2004.03.066.
Abstract
This paper summarizes results of the 40-year studies on replication and recombination of RNA molecules in the cell-free amplification system of bacteriophage Q. Special attention is paid to the molecular colony technique that has provided for the discovery of the nature of "spontaneous" RNA synthesis by Q replicase and of the ability of RNA molecules to spontaneously rearrange their sequences under physiological conditions. Also discussed is the impact of these data on the concept of RNA World and on the development of new in vitro cloning and diagnostic tools.
摘要
本文总结了在噬菌体Q的无细胞扩增系统中对RNA分子复制和重组进行的40年研究结果。特别关注分子集落技术，该技术使得人们发现了Q复制酶“自发”合成RNA的本质，以及RNA分子在生理条件下自发重排其序列的能力。还讨论了这些数据对RNA世界概念以及新型体外克隆和诊断工具开发的影响。
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