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自然选择会影响外显子5'端和3'端AG和GT二核苷酸的频率。

Natural selection affects frequencies of AG and GT dinucleotides at the 5' and 3' ends of exons.

作者信息

Eskesen S T, Eskesen F N, Ruvinsky A

机构信息

Institute for Genetics and Bioinformatics, University of New England, Armidale, New South Wales 2351, Australia.

出版信息

Genetics. 2004 May;167(1):543-50. doi: 10.1534/genetics.167.1.543.

DOI:10.1534/genetics.167.1.543
PMID:15166176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1470862/
Abstract

GT and AG, located at the 5' and 3' ends of introns, are important for correct splicing. It is anticipated that natural selection decreases frequency of AG and GT near the 5' and 3' ends of exons, preventing appearance of cryptic splicing sites. The data presented in this article support the expectation.

摘要

位于内含子5'端和3'端的GT和AG对正确剪接很重要。据推测，自然选择会降低外显子5'端和3'端附近AG和GT的频率，从而防止隐蔽剪接位点的出现。本文给出的数据支持这一推测。

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本文引用的文献

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Predictive identification of exonic splicing enhancers in human genes.人类基因中外显子剪接增强子的预测性识别。
Science. 2002 Aug 9;297(5583):1007-13. doi: 10.1126/science.1073774. Epub 2002 Jul 11.
2
Alternative pre-mRNA splicing and proteome expansion in metazoans.后生动物中的可变前体mRNA剪接与蛋白质组扩展
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Splicing regulation as a potential genetic modifier.剪接调控作为一种潜在的基因修饰因子。
Trends Genet. 2002 Mar;18(3):123-7. doi: 10.1016/s0168-9525(01)02619-1.
4
Codon usage bias covaries with expression breadth and the rate of synonymous evolution in humans, but this is not evidence for selection.密码子使用偏好与人类的表达广度和同义进化速率共变，但这并非选择的证据。
Genetics. 2001 Nov;159(3):1191-9. doi: 10.1093/genetics/159.3.1191.
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When the message goes awry: disease-producing mutations that influence mRNA content and performance.当信息出错时：影响mRNA含量和功能的致病突变
Cell. 2001 Nov 16;107(4):411-4. doi: 10.1016/s0092-8674(01)00583-9.
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The covariation between TpA deficiency, CpG deficiency, and G+C content of human isochores is due to a mathematical artifact.人类等染色体区中TpA缺失、CpG缺失与G+C含量之间的协变是一种数学假象。
Mol Biol Evol. 2000 Nov;17(11):1620-5. doi: 10.1093/oxfordjournals.molbev.a026261.
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Analysis of canonical and non-canonical splice sites in mammalian genomes.哺乳动物基因组中典型和非典型剪接位点的分析。
Nucleic Acids Res. 2000 Nov 1;28(21):4364-75. doi: 10.1093/nar/28.21.4364.
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EID: the Exon-Intron Database-an exhaustive database of protein-coding intron-containing genes.EID：外显子-内含子数据库——一个包含蛋白质编码含内含子基因的详尽数据库。
Nucleic Acids Res. 2000 Jan 1;28(1):185-90. doi: 10.1093/nar/28.1.185.
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What drives codon choices in human genes?是什么驱动了人类基因中的密码子选择？
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