Turgeon Judith L, McDonnell Donald P, Martin Kathryn A, Wise Phyllis M
Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California-Davis, Davis, CA 95616, USA.
Science. 2004 May 28;304(5675):1269-73. doi: 10.1126/science.1096725.
The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone therapy, have generated debate and confusion among clinicians, researchers, and the lay public. The ovarian hormones estrogen and progesterone, which decline at menopause, normally elicit complex tissue-specific responses throughout the body. Major advances are providing a detailed molecular definition of how that differential action is achieved. Here we review estrogen and progestin actions, discuss how effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies, and consider the impact on modern hormone therapy protocols and pharmaceutical development.
妇女健康倡议研究旨在就绝经后激素疗法的健康益处和风险给出明确答案，其结果在临床医生、研究人员和普通大众中引发了争论和困惑。卵巢激素雌激素和孕激素在绝经时会减少，通常会在全身引发复杂的组织特异性反应。重大进展正在为这种差异作用是如何实现提供详细的分子定义。在此，我们回顾雌激素和孕激素的作用，讨论甾体激素内分泌学知识在临床研究中的融入效果，并思考其对现代激素疗法方案和药物研发的影响。
