Kyd J M, Murdoch R N
Department of Biological Sciences, University of Newcastle, NSW, Australia.
Experientia. 1992 Aug 15;48(8):741-5. doi: 10.1007/BF02124291.
Intraluminal injections (15 microliters) of either concanavalin A (125 micrograms) or ionophore A 23,187 (0.01 mumol) induced a decidual cell reaction (DCR) in the uterus of day 4.5 pseudopregnant mice. However, when these agents were administered in different combinations with each other or with CaCl2 (15 mumol) and phorbol-12-myristate-13-acetate (1.6 nmol), interacting effects occurred to either enhance or inhibit each of the others' independent deciduogenic capacities. The results suggest that the polyphosphatidylinositol pathway and Ca2+ are involved in the induction of the DCR in mice with complex interactions occurring between the active components of the pathway to modulate the outcome of the transformation process.
向第4.5天假孕小鼠子宫内注射（15微升）伴刀豆球蛋白A（125微克）或离子载体A 23,187（0.01微摩尔）可诱导蜕膜细胞反应（DCR）。然而，当这些试剂相互或以不同组合与氯化钙（15微摩尔）和佛波醇-12-肉豆蔻酸酯-13-乙酸酯（1.6纳摩尔）一起给药时，会产生相互作用效应，增强或抑制其他试剂各自的独立蜕膜诱导能力。结果表明，多磷脂酰肌醇途径和Ca2+参与了小鼠DCR的诱导，该途径的活性成分之间发生复杂相互作用，以调节转化过程的结果。
