[俄罗斯中部地区结核病患者中分离出的临床结核分枝杆菌菌株的寡核苷酸分型]
[Spoligotypes of clinical Mycobacterium tuberculosis strains isolated in patients with tuberculosis in the Central Region of Russia].
作者信息
Ivanov I Iu, Stepanshina V N, Lipin M Iu, Korobova O V, Shemiakin I G
出版信息
Probl Tuberk Bolezn Legk. 2004(4):23-7.
Spoligotyping and RFLP-IS6110 techniques were used to analyze 353 clinical Mycobacterium tuberculosis strains isolated from patients with tuberculosis in the Central Region of Russia. All spoligotypes were classified according to the international database. Most clinical M. tuberculosis strains in the collection obtained from patients living in the Central Region of Russia belong to the LAM (49.6%) and Beijing (34%) families, as shown by spoligotyping, and to A1 (51.3%) and W (34%) families, as evidenced by the RFLP-IS6110 technique.
采用间隔寡核苷酸分型（Spoligotyping）和限制性片段长度多态性-IS6110（RFLP-IS6110）技术，对从俄罗斯中部地区结核病患者中分离出的353株临床结核分枝杆菌菌株进行分析。所有间隔寡核苷酸分型均根据国际数据库进行分类。间隔寡核苷酸分型结果显示，从俄罗斯中部地区患者中收集的大多数临床结核分枝杆菌菌株属于LAM家族（49.6%）和北京家族（34%）；RFLP-IS6110技术结果表明，这些菌株属于A1家族（51.3%）和W家族（34%）。
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