一种基于DNA芯片的结核分枝杆菌分离株菌株鉴定的寡核苷酸分型方法。
A DNA chip-based spoligotyping method for the strain identification of Mycobacterium tuberculosis isolates.
作者信息
Song Eun Ju, Jeong Hae Jin, Lee Sun Min, Kim Cheol Min, Song Eun Sil, Park Young Kil, Bai Gill-Han, Lee Eun Yup, Chang Chulhun L
机构信息
Department of Laboratory Medicine, School of Medicine, Pusan National University, Seo-Gu Ami-Dong 1-10, Busan 602-739, Republic of Korea.
出版信息
J Microbiol Methods. 2007 Feb;68(2):430-3. doi: 10.1016/j.mimet.2006.09.005. Epub 2006 Oct 12.
The clinical efficacy of a spoligotyping method for discriminating Mycobacterium tuberculosis strains was evaluated. Among the strains other than Beijing or Beijing like family, 30 different spoligotypes out of 39 strains were produced, which included 4 strains not having IS6110 sequence. The oligonucleotide chip-based spoligotyping technique is useful for early screening and detection of clonal proximity of M. tuberculosis isolates.
评估了一种用于区分结核分枝杆菌菌株的间隔寡核苷酸分型方法的临床疗效。在非北京或类北京家族的菌株中，39株菌株产生了30种不同的间隔寡核苷酸分型，其中包括4株没有IS6110序列的菌株。基于寡核苷酸芯片的间隔寡核苷酸分型技术可用于结核分枝杆菌分离株的早期筛查和克隆亲缘关系检测。
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