类风湿关节炎患者接受生物治疗时结核病风险及治疗的考量。
Consideration of the risk and treatment of tuberculosis in patients who have rheumatoid arthritis and receive biologic treatments.
作者信息
Bieber Jeffry, Kavanaugh Arthur
机构信息
Division of Rheumatology, Allergy, and Immunology, Department of Medicine, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037-0943, USA.
出版信息
Rheum Dis Clin North Am. 2004 May;30(2):257-70, v. doi: 10.1016/j.rdc.2004.01.003.
Evidence supports the association of tuberculosis (TB) with tumor necrosis factor inhibitor therapy in patients who have rheumatoid arthritis. There seem to be differential risks of TB with the currently available inhibitors. Screening for latent TB infection with purified protein derivative is indicated for patients who are being considered for treatment; it seems to be effective in reducing the occurrence of TB in treated patients.
有证据支持类风湿关节炎患者中结核病（TB）与肿瘤坏死因子抑制剂治疗之间的关联。目前可用的抑制剂导致结核病的风险似乎存在差异。对于正在考虑接受治疗的患者，建议使用纯化蛋白衍生物筛查潜伏性结核感染；这似乎对降低接受治疗患者的结核病发生率有效。
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