Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans.

作者信息

Chabane Nadia, Millet Bruno, Delorme Richard, Lichtermann Dirk, Mathieu Flavie, Laplanche Jean Louis, Roy Isabelle, Mouren Marie Christine, Hankard Regis, Maier Wolfgang, Launay Jean Marie, Leboyer Marion

机构信息

University Department of Psychiatry, INSERM E0 117, Sainte-Anne Hospital, Paris, France.

出版信息

Neurosci Lett. 2004 Jun 10;363(2):154-6. doi: 10.1016/j.neulet.2004.03.065.

DOI:10.1016/j.neulet.2004.03.065

PMID:15172105

Abstract

Association studies of the serotonin transporter (SLC6A4) gene in obsessive-compulsive disorder (OCD) have generated discrepant results. Here, we genotyped the 5-HTTLPR polymorphism in 106 French OCD patients and 171 healthy controls (case control study). We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study.

摘要