活动性多发性硬化症中CD14+CCR2+单核细胞减少。

Decreased CD14+CCR2+ monocytes in active multiple sclerosis.

作者信息

Nakajima Hideto, Sugino Masakazu, Kimura Fumiharu, Hanafusa Toshiaki, Ikemoto Toshiyuki, Shimizu Akira

机构信息

First Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki City, Osaka 569-8686, Japan.

出版信息

Neurosci Lett. 2004 Jun 10;363(2):187-9. doi: 10.1016/j.neulet.2004.04.006.

DOI:10.1016/j.neulet.2004.04.006

PMID:15172112

Abstract

The expression of CCR2, a receptor to MCP-1, on blood monocytes was measured in 15 patients with active multiple sclerosis (MS). We determined the ratio of CD4+CXCR3+cells (Th1), CD4+CCR4+cells (Th2), and CD14+CCR2+ cells using 3-color flow cytometry. The CD4+CXCR3+/CD4+CCR4+ ratio, which represents the Th1/Th2 balance, was significantly elevated in the active MS patients compared to the healthy controls. The expression of CCR2 and CD14 on the monocytes in the MS patients was markedly decreased. There was a significant negative correlation between the Th1/Th2 ratio and the CCR2 and CD14 expression on monocytes. In the pathogenesis of MS, the CD14+CCR2+ blood monocytes may play an important role in the shift from active MS to a state in which the disease is in remission.

摘要

在15例活动性多发性硬化症（MS）患者中，检测了血液单核细胞上MCP - 1的受体CCR2的表达。我们使用三色流式细胞术测定了CD4 + CXCR3 +细胞（Th1）、CD4 + CCR4 +细胞（Th2）和CD14 + CCR2 +细胞的比例。代表Th1/Th2平衡的CD4 + CXCR3 + /CD4 + CCR4 +比值在活动性MS患者中显著高于健康对照。MS患者单核细胞上CCR2和CD14的表达明显降低。Th1/Th2比值与单核细胞上CCR2和CD14的表达之间存在显著负相关。在MS的发病机制中，CD14 + CCR2 +血液单核细胞可能在活动性MS向疾病缓解状态的转变中起重要作用。