一氧化碳中毒中的S100B蛋白：一项初步研究。

S100B protein in carbon monoxide poisoning: a pilot study.

作者信息

Brvar Miran, Mozina Hugon, Osredkar Josko, Mozina Martin, Noc Marko, Brucan Andrej, Bunc Matjaz

机构信息

Poison Control Center, Ljubljana Medical Center, Zaloska Cesta 7, 1000 Ljubljana, Slovenia.

出版信息

Resuscitation. 2004 Jun;61(3):357-60. doi: 10.1016/j.resuscitation.2004.01.009.

DOI:10.1016/j.resuscitation.2004.01.009

PMID:15172716

Abstract

Carbon monoxide (CO) poisoning is the most common form of lethal poisoning. The aim of this prospective clinical study was to assess the possible role of S100B, the structural protein in the astroglia, as a biochemical marker of brain injury in carbon monoxide poisoning. Serum S100B determination was performed in 38 consecutive patients poisoned by carbon monoxide who were admitted to the Emergency Department (ED) in Ljubljana. All three unconscious patients had elevated S100B levels. The patient with the highest S100B died. S100B was elevated in two of the six patients with initial transitory unconsciousness at the scene. All 29 patients without loss of consciousness had normal S100B levels. Carbon monoxide poisoning appears to be associated with elevated S100B levels.

摘要

一氧化碳（CO）中毒是最常见的致死性中毒形式。这项前瞻性临床研究的目的是评估星形胶质细胞中的结构蛋白S100B作为一氧化碳中毒脑损伤生化标志物的可能作用。对卢布尔雅那急诊科收治的38例连续一氧化碳中毒患者进行了血清S100B测定。所有3例昏迷患者的S100B水平均升高。S100B水平最高的患者死亡。6例在现场最初有短暂昏迷的患者中有2例S100B升高。所有29例未丧失意识的患者S100B水平正常。一氧化碳中毒似乎与S100B水平升高有关。