Yardan Turker, Cevik Yunsur, Donderici Omer, Kavalci Cemil, Yilmaz Fatma Meric, Yilmaz Gulsen, Vural Kubilay, Yuzbasioglu Yucel, Gunaydin Yahya Kemal, Sezer Ahmet Ali
Faculty of Medicine, Department of Emergency Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey.
Am J Emerg Med. 2009 Sep;27(7):838-42. doi: 10.1016/j.ajem.2008.04.016.
Carbon monoxide (CO) poisoning causes cerebral and generalized hypoxia. This study aimed to assess the possible use of serum glial marker S100B protein and neuron-specific enolase (NSE) as biochemical markers of hypoxic brain damage in acute CO poisoning.
Patients with acute CO poisoning admitted to the ED of 2 training hospitals (Ankara, Turkey) were included in this cross-sectional study. Serum levels of S100B and NSE were measured on admission. The patients were divided into 2 groups (unconscious and conscious). Twenty healthy adults were included in the study to serve as controls.
A total of 70 patients poisoned by CO (mean age +/- SD, 36.6 +/- 16.3 years; 64.3% women) were enrolled. Although S100B concentrations were higher in patients than in the control group (P = .018), no significant difference was determined between patient and control groups with respect to NSE concentrations (P = .801). A positive correlation was noted between levels of S100B and NSE (r = 0.388; P = .001). The S100B and NSE values were higher in unconscious patients than in the control group (P = .002 and P = .013, respectively). Furthermore, S100B and NSE values were higher in unconscious vs unconscious patients (P = .047 and P = .005, respectively).
Elevated serum S100B and NSE levels were associated with loss of consciousness in CO poisoning in this series of patients. Serum S100B and NSE may be useful markers in the assessment of clinical status in CO poisoning.
一氧化碳（CO）中毒会导致脑和全身缺氧。本研究旨在评估血清神经胶质标志物S100B蛋白和神经元特异性烯醇化酶（NSE）作为急性CO中毒时缺氧性脑损伤生化标志物的可能性。
本横断面研究纳入了土耳其安卡拉2家培训医院急诊科收治的急性CO中毒患者。入院时测定血清S100B和NSE水平。患者分为2组（昏迷组和清醒组）。纳入20名健康成年人作为对照。
共纳入70例CO中毒患者（平均年龄±标准差，36.6±16.3岁；64.3%为女性）。虽然患者组的S100B浓度高于对照组（P = 0.018），但患者组和对照组之间的NSE浓度无显著差异（P = 0.801）。S100B和NSE水平之间呈正相关（r = 0.388；P = 0.001）。昏迷患者的S100B和NSE值高于对照组（分别为P = 0.002和P = 0.013）。此外，昏迷患者的S100B和NSE值高于清醒患者（分别为P = 0.047和P = 0.005）。
在这一系列患者中，血清S100B和NSE水平升高与CO中毒导致的意识丧失有关。血清S100B和NSE可能是评估CO中毒临床状况的有用标志物。
