CD8(+) T细胞上的CD4直接增强效应功能，并且是HIV感染的一个靶点。
CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection.
作者信息
Kitchen Scott G, Jones Nicole R, LaForge Stuart, Whitmire Jason K, Vu Bien-Aimee, Galic Zoran, Brooks David G, Brown Stephen J, Kitchen Christina M R, Zack Jerome A
机构信息
Department of Medicine and Microbiology, David Geffen School of Medicine, University of California, 11-934 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
出版信息
Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8727-32. doi: 10.1073/pnas.0401500101. Epub 2004 Jun 1.
Costimulation of purified CD8(+) T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4 molecule plays a direct role in CD8(+) T cell function by modulating expression of IFN-gamma and Fas ligand, two important CD8(+) T cell effector molecules. CD4 expression also allows infection of CD8 cells by HIV, which results in down-regulation of the CD4 molecule and impairs the induction of IFN-gamma, Fas ligand, and the cytotoxic responses of activated CD8(+) T cells. Thus, the CD4 molecule plays a direct role in CD8 T cell function, and infection of these cells by HIV provides an additional reservoir for the virus and also may contribute to the immunodeficiency seen in HIV disease.
对纯化的CD8(+) T淋巴细胞进行共刺激会诱导CD4的从头表达，这表明该分子在免疫反应中具有先前未被认识到的功能。在此，我们报告CD4分子通过调节IFN-γ和Fas配体（两种重要的CD8(+) T细胞效应分子）的表达，在CD8(+) T细胞功能中发挥直接作用。CD4的表达还使HIV能够感染CD8细胞，这导致CD4分子下调，并损害IFN-γ、Fas配体的诱导以及活化的CD8(+) T细胞的细胞毒性反应。因此，CD4分子在CD8 T细胞功能中发挥直接作用，HIV对这些细胞的感染为病毒提供了额外的储存库，也可能导致HIV疾病中出现的免疫缺陷。
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