来自维罗尼卡叶布氏菊的5,7,3'-三羟基-3,6,4'-三甲氧基黄酮的抗氧化和自由基清除活性

Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia.

作者信息

Pérez G R M, Vargas S R, Martinez M F J, Cordova R I

机构信息

Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingeniería Química e Industias extractivas IPN, Punto fi jo 16, col. Torres Lindavista cp 07708, México D.F. México.

出版信息

Phytother Res. 2004 May;18(5):428-30. doi: 10.1002/ptr.1445.

DOI:10.1002/ptr.1445

PMID:15174007

Abstract

The antioxidant and antiradical activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone or centaureidin isolated and characterized from Brickellia veronicaefolia were elucidated by heat-induced oxidation in a beta-carotene and linoleic acid system and by the 1,1-diphenyl-2-picrylhydrazyl decoloration test. The centaureidin (32.1%) exhibited antioxidative activity less than that of BHT (95.5%) and alpha-tocopherol (95.9%) on oxidation in a beta-carotene and linoleic acid system. A moderate antiradical effect (47.6%) compared with BHT (96.7%) and alpha-tocopherol (94.6%) in DPPH decoloration test was found.

摘要

从维罗尼卡叶布里克尔菊中分离并鉴定出的5,7,3'-三羟基-3,6,4'-三甲氧基黄酮或矢车菊素的抗氧化和抗自由基活性，通过β-胡萝卜素和亚油酸体系中的热诱导氧化以及1,1-二苯基-2-苦基肼脱色试验进行了阐明。在β-胡萝卜素和亚油酸体系的氧化中，矢车菊素（32.1%）表现出的抗氧化活性低于丁基羟基甲苯（BHT，95.5%）和α-生育酚（95.9%）。在二苯代苦味酰基自由基（DPPH）脱色试验中，与BHT（96.7%）和α-生育酚（94.6%）相比，发现其具有中等的抗自由基效果（47.6%）。