散发性腹泻病例中产气荚膜梭菌及其肠毒素的检测
Detection of Clostridium perfringens and its enterotoxin in cases of sporadic diarrhoea.
作者信息
Brett M M, Rodhouse J C, Donovan T J, Tebbutt G M, Hutchinson D N
机构信息
Food Hygiene Laboratory, Central Public Health Laboratory, London.
出版信息
J Clin Pathol. 1992 Jul;45(7):609-11. doi: 10.1136/jcp.45.7.609.
Abstract
AIMS
To determine the incidence of sporadic and apparently non-food related diarrhoea associated with Clostridium perfringens enterotoxin.
METHODS
Enzyme linked immunosorbent assay (ELISA) and reversed phase latex agglutination (RPLA) were used to detect C perfringens enterotoxin in faecal specimens from 818 sporadic cases of diarrhoea.
RESULTS
C perfringens enterotoxin was identified as a cause of sporadic diarrhoea in 56 of 818 (6.8%) cases. Diarrhoea was prolonged (three days or more) in most cases. Ages ranged from 3 months to 89 years, although most patients were over 60 years of age.
CONCLUSIONS
These results suggest that C perfringens may be a cause of sporadic cases of diarrhoea when causes such as food consumption or cross-infection are absent, particularly in the elderly.
摘要
目的
确定与产气荚膜梭菌肠毒素相关的散发性且明显与食物无关的腹泻发病率。
方法
采用酶联免疫吸附测定（ELISA）和反向乳胶凝集试验（RPLA）检测818例散发性腹泻病例粪便标本中的产气荚膜梭菌肠毒素。
结果
818例病例中有56例（6.8%）的散发性腹泻病因被确定为产气荚膜梭菌肠毒素。多数病例腹泻持续时间较长（三天或更长时间）。年龄范围从3个月至89岁，不过多数患者年龄超过60岁。
结论
这些结果表明，在不存在食物摄入或交叉感染等病因的情况下，产气荚膜梭菌可能是散发性腹泻病例的病因，尤其是在老年人中。
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