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副溶血性弧菌中的交叉调控:侧向鞭毛调节因子LafK对极性鞭毛基因的代偿性激活。

Cross-regulation in Vibrio parahaemolyticus: compensatory activation of polar flagellar genes by the lateral flagellar regulator LafK.

作者信息

Kim Yun-Kyeong, McCarter Linda L

机构信息

Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA.

出版信息

J Bacteriol. 2004 Jun;186(12):4014-8. doi: 10.1128/JB.186.12.4014-4018.2004.

Abstract

Gene organization and hierarchical regulation of the polar flagellar genes of Vibrio parahaemolyticus, Vibrio cholerae, and Pseudomonas aeruginosa appear highly similar, with one puzzling difference. Two sigma(54)-dependent regulators are required to direct different classes of intermediate flagellar gene expression in V. cholerae and P. aeruginosa, whereas the V. parahaemolyticus homolog of one of these regulators, FlaK, appears dispensable. Here we demonstrate that there is compensatory activation of polar flagellar genes by the lateral flagellar regulator LafK.

摘要

副溶血性弧菌、霍乱弧菌和铜绿假单胞菌的极鞭毛基因的基因组织和层级调控似乎高度相似,但有一个令人困惑的差异。在霍乱弧菌和铜绿假单胞菌中,需要两个依赖σ⁵⁴的调节因子来指导不同类别的中间鞭毛基因表达,而其中一个调节因子FlaK在副溶血性弧菌中的同源物似乎是可有可无的。在这里,我们证明侧向鞭毛调节因子LafK对极鞭毛基因有补偿性激活作用。

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