Herdzik Edyta, Ciechanowski Kazimierz, Kabat-Koperska Joanna, Kedzierska Karolina
Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych PAM w Szczecinie.
Pol Merkur Lekarski. 2004 Feb;16(92):196-8.
Osmotic demyelination syndrome is an iatrogenic disease related to inappropriately rapid correction of plasma osmolar disorders. The precise mechanism of injury is still unknown. Focal demyelination may appear in pontine (central pontine myelinosis, CPM) and extrapontine locations (extrapontine myelinosis, EPM), determining clinical manifestations of the disease. Modern techniques of radiological imaging like MRI play important role in demyelination syndrome diagnosis. The knowledge of conditions associated with an increased risk of osmotic demyelination syndrome and careful management of osmotic disturbances according to current standards may contribute to improved prognosis in this disease.
渗透性脱髓鞘综合征是一种与血浆渗透压紊乱纠正过快不当相关的医源性疾病。确切的损伤机制尚不清楚。局灶性脱髓鞘可能出现在脑桥(中枢性脑桥髓鞘溶解症,CPM)和脑桥外部位(脑桥外髓鞘溶解症,EPM),决定了该疾病的临床表现。像MRI这样的现代放射影像学技术在脱髓鞘综合征诊断中发挥着重要作用。了解与渗透性脱髓鞘综合征风险增加相关的情况,并根据当前标准仔细管理渗透压紊乱,可能有助于改善该疾病的预后。