Alkali N H, Jibrin Y B, Dunga J A, Abdu A
Department of Medicine, Abubakar Tafawa Balewa University Teaching Hospital, PMB 0117, Bauchi, Bauchi State, Nigeria.
Niger J Clin Pract. 2019 Aug;22(8):1166-1168. doi: 10.4103/njcp.njcp_542_18.
Osmotic demyelination syndrome (ODS) is a life-threatening neurological condition often associated with rapid correction of hyponatremia. While ODS is thought to be rare, with prevalence rates of not more than 0.5% in autopsy series, mortality rates are as high as 90% in some studies. Thus, timely diagnosis and life-saving treatment rest on a high index of suspicion among clinicians. In this report, we discuss the case and literature review of a 45-year-old female with sepsis, acute kidney injury, and spontaneous hypernatremia who developed ODS but responded to therapy with high dose steroids, antibiotics, and supportive care.
渗透性脱髓鞘综合征（ODS）是一种危及生命的神经系统疾病，常与低钠血症的快速纠正有关。虽然ODS被认为较为罕见，尸检系列中的患病率不超过0.5%，但在一些研究中死亡率高达90%。因此，及时诊断和挽救生命的治疗依赖于临床医生的高度怀疑指数。在本报告中，我们讨论了一例45岁女性的病例及文献回顾，该患者患有脓毒症、急性肾损伤和自发性高钠血症，并发ODS，但对大剂量类固醇、抗生素和支持治疗有反应。
