Larregina A, Bartoletti B, Romano H, Paniccia L, Polini N N
Hospital Municipal de Agudos Dr Leónidas Lucero, Servicios de Hematología, Hemoterapia, Clínica Medica y Laboratorio Central, Estomba 968, 8000 Bahía Blanca, Argentina.
Rev Argent Microbiol. 2004 Jan-Mar;36(1):28-30.
Chronic diseminated candidiasis--mainly its hepatosplenic form- is one of the most characteristic invasive infection due to Candida in haematological patients. A case is presented of a 31 year old man admitted to the Clinical Department with acute mieloid leukosis M2, showing febrile neutropenia after induction and consolidation chemotherapy. Hepatoesplenic candidiasis was diagnosed and confirmed by computered axial tomography (CAT) and hepatic biopsy; amphotericin B followed by liposome encapsuled amphotericin B up to complete a total dose of 4 g was used for treatment. The patient was discharged waiting for bone marrow transplantation. Early suspicion of hepatosplenic candidiasis helps to select a rapid diagnosis method and an effective treatment.
慢性播散性念珠菌病——主要是肝脾型——是血液系统疾病患者中最具特征性的念珠菌侵袭性感染之一。本文报告一例31岁男性患者,因急性髓系白血病M2入住临床科室,诱导缓解及巩固化疗后出现发热性中性粒细胞减少。经计算机断层扫描(CAT)和肝脏活检诊断并确诊为肝脾念珠菌病;使用两性霉素B,随后使用脂质体包裹的两性霉素B,直至总剂量达到4g进行治疗。患者出院等待骨髓移植。早期怀疑肝脾念珠菌病有助于选择快速诊断方法和有效治疗方案。