炎症性肠病的药物治疗总则

General principles of medical therapy of inflammatory bowel disease.

作者信息

Friedman Sonia

机构信息

Gastroenterology Division ASBII, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

出版信息

Gastroenterol Clin North Am. 2004 Jun;33(2):191-208, viii. doi: 10.1016/j.gtc.2004.02.003.

DOI:10.1016/j.gtc.2004.02.003

PMID:15177534

Abstract

Ulcerative colitis and Crohn's disease are chronic gastrointestinal diseases that affect patients in the prime of their lives. Because inflammatory bowel disease (IBD) patients generally live a normal lifespan, chronic medical therapy for IBD must be tolerable, simple to adhere to, and have as few side effects as possible. This article discusses the impact of IBD on quality of life and stresses the importance of appropriate and individualized medical therapy. To help clinicians determine the efficacy of particular IBD medications, this article offers a brief, practical interpretation of clinical, endoscopic, and quality-of-life end points used in clinical trials. Finally, it provides a summary of the current accepted medical therapies for ulcerative colitis adn Crohn's disease and recommendations for using these medications in clinical practice.

摘要

溃疡性结肠炎和克罗恩病是影响青壮年患者的慢性胃肠疾病。由于炎症性肠病（IBD）患者通常可正常寿命，IBD的慢性药物治疗必须是可耐受的、易于坚持的且副作用尽可能少。本文讨论了IBD对生活质量的影响，并强调了适当和个体化药物治疗的重要性。为帮助临床医生确定特定IBD药物的疗效，本文对临床试验中使用的临床、内镜和生活质量终点进行了简要、实用的解读。最后，本文总结了目前公认的溃疡性结肠炎和克罗恩病的药物治疗方法以及在临床实践中使用这些药物的建议。