Aberra F N, Lichtenstein G R
Department of Medicine, Center for Inflammatory Bowel Disease, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, 3400 Spruce Street, 3rd floor Ravdin Building, Philadelphia, PA 19104-4283, USA.
Aliment Pharmacol Ther. 2005 Feb 15;21(4):307-19. doi: 10.1111/j.1365-2036.2005.02343.x.
The armamentarium of medications for the treatment of inflammatory bowel disease is growing and becoming more complicated to use. Immunomodulators are a class of medications that have found a niche for the treatment of Crohn's disease and ulcerative colitis. Because of the mounting supporting evidence for efficacy, the most commonly-used immunomodulators are azathioprine, mercaptopurine, methotrexate and ciclosporin. These medications are being used more often due to their steroid-sparing and potentially surgery-sparing effects. Immunomodulators are also known for a significant side-effect profile and require careful monitoring. This review provides the latest information for clinicians on efficacy, side-effects, dosing and monitoring of these medications for treatment of inflammatory bowel disease.
用于治疗炎症性肠病的药物种类不断增加，使用起来也变得更加复杂。免疫调节剂是一类已在克罗恩病和溃疡性结肠炎治疗中占据一席之地的药物。由于越来越多的证据支持其疗效，最常用的免疫调节剂是硫唑嘌呤、巯嘌呤、甲氨蝶呤和环孢素。这些药物因其节省类固醇和可能节省手术的作用而被更频繁地使用。免疫调节剂也以具有显著的副作用而闻名，需要仔细监测。本综述为临床医生提供了有关这些药物治疗炎症性肠病的疗效、副作用、给药和监测的最新信息。
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