链球菌和流感嗜血杆菌中的大环内酯类耐药性。

Macrolide resistance in Streptococci and Haemophilus influenzae.

作者信息

Bozdogan Bülent, Appelbaum Peter C

机构信息

Department of Pathology, Hershey Medical Center, 500 University Drive, Pennsylvania State University, Hershey, PA 17033, USA.

出版信息

Clin Lab Med. 2004 Jun;24(2):455-75. doi: 10.1016/j.cll.2004.03.006.

DOI:10.1016/j.cll.2004.03.006

PMID:15177849

Abstract

Antimicrobial resistance is a growing problem among pathogens from respiratory tract infections. b-Lactam resistance rates are escalating among Streptococcus pneumoniae and Haemophilus influenzae. Macrolides are increasingly used for the treatment of respiratory tract infections, but their utility is compromised by intrinsic and acquired resistance. This article analyses macrolide-resistance mechanisms and their worldwide distributions in S pneumoniae, S pyogenes, and H influenzae.

摘要

抗菌药物耐药性在呼吸道感染病原体中是一个日益严重的问题。肺炎链球菌和流感嗜血杆菌对β-内酰胺类药物的耐药率正在上升。大环内酯类药物越来越多地用于治疗呼吸道感染，但其效用因固有耐药性和获得性耐药性而受到影响。本文分析了肺炎链球菌、化脓性链球菌和流感嗜血杆菌中大环内酯类药物的耐药机制及其在全球的分布情况。