台湾地区减少红霉素使用后呼吸道病原体对大环内酯类抗生素耐药性的变化。
Changes in macrolide resistance among respiratory pathogens after decreased erythromycin consumption in Taiwan.
作者信息
Hsueh P-R, Shyr J-M, Wu J-J
机构信息
Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei.
出版信息
Clin Microbiol Infect. 2006 Mar;12(3):296-8. doi: 10.1111/j.1469-0691.2005.01348.x.
Measures to alleviate the growing problem of macrolide resistance in Taiwan resulted in a decrease in macrolide consumption, from 0.629 defined daily doses/1000 inhabitants per day (DIDs) in 1999 to 0.301 DIDs in 2003 (a reduction of 52%). A linear relationship was observed between the decline in erythromycin consumption and the decline in erythromycin resistance in Streptococcus pyogenes (46% in 1999 vs. 17% in 2003; p < 0.001) and azithromycin resistance in Haemophilus influenzae (31% in 2000 vs. 0% in 2003; p < 0.001). However, the rate of erythromycin resistance in Streptococcus pneumoniae showed a continued increase, from 80.2% in 1999 to 92% in 2003.
台湾采取的缓解大环内酯类耐药性这一日益严重问题的措施，使得大环内酯类药物的消耗量有所下降，从1999年的0.629限定日剂量/1000居民每日（DIDs）降至2003年的0.301 DIDs（降幅达52%）。观察到红霉素消耗量的下降与化脓性链球菌中红霉素耐药性的下降之间存在线性关系（1999年为46%，2003年为17%；p<0.001），以及与流感嗜血杆菌中阿奇霉素耐药性的下降之间存在线性关系（2000年为31%，2003年为0%；p<0.001）。然而，肺炎链球菌中红霉素耐药率持续上升，从1999年的80.2%升至2003年的92%。
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