采用液相色谱-电喷雾质谱法分析马钱子解毒种子中的士的宁[校正后]
Analysis of strychnine from detoxified Strychnos nux-vomica [corrected] seeds using liquid chromatography-electrospray mass spectrometry.
作者信息
Choi Young Hae, Sohn You-Min, Kim Chul Young, Oh Kwan Yul, Kim Jinwoong
机构信息
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
出版信息
J Ethnopharmacol. 2004 Jul;93(1):109-12. doi: 10.1016/j.jep.2004.03.038.
The content of strychnine from Strychnos nux-vomica [corrected] seeds was analyzed and compared to processed seeds by the HPLC-ESI/MS method. Using this technique, levels as low as 1 ng of strychnine were detected. In contrast to conventional UV detectors, this method also made it possible to discriminate brucine. This study resulted in finding the content of strychnine in detoxified seeds to be one tenth of unprocessed Strychnos nux-vomica [corrected] seeds.
采用高效液相色谱-电喷雾电离质谱法（HPLC-ESI/MS）对马钱子种子的士的宁含量进行了分析，并与炮制后的种子进行了比较。利用该技术，检测到低至1纳克的士的宁含量。与传统的紫外检测器不同，该方法还能够区分马钱子碱。该研究发现，解毒后的种子的士的宁含量是未加工马钱子种子的士的宁含量的十分之一。
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