Zhang Jian
Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Clin Immunol. 2004 Jun;111(3):234-40. doi: 10.1016/j.clim.2004.02.003.
Ubiquitination-mediated protein modifications are increasingly recognized as key regulatory events in many basic cell biology processes. A key class of enzymes called ubiquitin ligases, which has been shown to play a crucial role in the ubiquitination process, can positively or negatively regulate T cell responses. This review summarizes the recent advances defining the roles of several ubiquitin ligases in T cell activation and autoimmunity.
泛素化介导的蛋白质修饰在许多基本细胞生物学过程中日益被视为关键的调控事件。一类名为泛素连接酶的关键酶已被证明在泛素化过程中发挥关键作用，它可以正向或负向调节T细胞反应。本综述总结了近期在确定几种泛素连接酶在T细胞活化和自身免疫中作用方面取得的进展。
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