Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Pathology, The University of Iowa, Iowa City, IA, United States.
Front Immunol. 2018 Feb 1;9:123. doi: 10.3389/fimmu.2018.00123. eCollection 2018.
Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.
在所有病原体识别受体家族中，C 型凝集素受体 (CLR) 诱导的细胞内信号级联反应对于启动和调节抗真菌免疫是必不可少的。过去十年的持续研究揭示了 CLR 的多种功能和 CLR 介导的信号通路的新调节机制。在这篇综述中，我们强调了 CLR 介导的抗真菌先天和适应性保护免疫的新见解，并讨论了基于针对宿主免疫系统中的介质的潜在治疗策略来对抗真菌感染。
