足月儿和早产儿的血小板功能

Platelet function in term and preterm neonates.

作者信息

Saxonhouse Matthew A, Sola Martha C

机构信息

Division of Neonatology, Department of Pediatrics, University of Florida, College of Medicine, P.O. Box 100296, 1600 SW Archer Road, Gainesville, FL 32610, USA.

出版信息

Clin Perinatol. 2004 Mar;31(1):15-28. doi: 10.1016/j.clp.2004.03.009.

DOI:10.1016/j.clp.2004.03.009

PMID:15183653

Abstract

Platelet dysfunction likely contributes to the pathophysiology of catastrophic hemorrhages in preterm neonates. In vitro studies have demonstrated that platelets of both term and preterm neonates are hyporesponsive to a variety of agonists. In contrast,template bleeding times of term neonates are shorter than those from adults. Very little is known about this and other tests of primary hemostasis in premature and sick neonates in the neonatal intensive care unit (NICU). This article covers the current knowledge of platelet function in preterm and term neonates and review show new agents (such as recombinant thrombopoietin and recombinant factor VIIa) may enhance neonatal platelet function.

摘要

血小板功能障碍可能在早产儿灾难性出血的病理生理过程中起作用。体外研究表明，足月儿和早产儿的血小板对多种激动剂反应低下。相比之下，足月儿的模板出血时间比成年人短。对于新生儿重症监护病房（NICU）中早产和患病新生儿的这一情况以及其他初级止血测试，人们了解甚少。本文涵盖了目前关于早产儿和足月儿血小板功能的知识，并综述了新型药物（如重组血小板生成素和重组凝血因子VIIa）可能增强新生儿血小板功能。