选择性刺激中枢去甲肾上腺素后运动技能习得得到改善。
Improved motor skill acquisition after selective stimulation of central norepinephrine.
作者信息
Plewnia Christian, Hoppe Julia, Cohen Leonardo G, Gerloff Christian
机构信息
Cortical Physiology Research Group, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany.
出版信息
Neurology. 2004 Jun 8;62(11):2124-6. doi: 10.1212/01.wnl.0000128041.92710.17.
It has been proposed that the beneficial effects of training on motor function can be enhanced by stimulation of alpha-adrenergic mechanisms. Consistent with this view, a single oral dose of the selective norepinephrine reuptake inhibitor reboxetine was found to enhance motor skill acquisition (rapid elbow flexion) and corticomotor excitability tested with transcranial magnetic stimulation in the absence of effects on basal motor performance. Therefore, alpha-adrenergic mechanisms could possibly be manipulated to magnify training effects in neurorehabilitation.
有人提出，通过刺激α-肾上腺素能机制，可以增强训练对运动功能的有益影响。与这一观点一致的是，研究发现，单次口服选择性去甲肾上腺素再摄取抑制剂瑞波西汀，可增强运动技能习得（快速屈肘），并在不影响基础运动表现的情况下，通过经颅磁刺激测试增强皮质运动兴奋性。因此，α-肾上腺素能机制可能可以被操控，以放大神经康复中的训练效果。
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