School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Dept. Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.
Int J Neuropsychopharmacol. 2021 Jul 14;24(6):490-498. doi: 10.1093/ijnp/pyab006.
Noradrenaline has an important role as a neuromodulator of the central nervous system. Noradrenergic enhancement was recently shown to enhance glutamate-dependent cortical facilitation and long term potentiation-like plasticity. As cortical excitability and plasticity are closely linked to various cognitive processes, here we aimed to explore whether these alterations are associated with respective cognitive performance changes. Specifically, we assessed the impact of noradrenergic enhancement on motor learning (serial reaction time task), attentional processes (Stroop interference task), and working memory performance (n-back letter task).
The study was conducted in a cross-over design. Twenty-five healthy humans performed the respective cognitive tasks after a single dose of the noradrenaline reuptake inhibitor reboxetine or placebo administration.
The results show that motor learning, attentional processes, and working memory performance in healthy participants were improved by reboxetine application compared with placebo.
The results of the present study thus suggest that noradrenergic enhancement can improve memory formation and executive functions in healthy humans. The respective changes are in line with related effects of noradrenaline on cortical excitability and plasticity.
去甲肾上腺素作为中枢神经系统的神经调质具有重要作用。最近的研究表明，去甲肾上腺素能增强作用可增强谷氨酸依赖性皮质易化和类长时程增强可塑性。由于皮质兴奋性和可塑性与各种认知过程密切相关，因此我们旨在探索这些变化是否与相应的认知表现变化相关。具体来说，我们评估了去甲肾上腺素能增强对运动学习（序列反应时间任务）、注意力过程（Stroop 干扰任务）和工作记忆表现（n-回字母任务）的影响。
该研究采用交叉设计进行。二十五名健康人在单次给予去甲肾上腺素再摄取抑制剂瑞波西汀或安慰剂后进行了各自的认知任务。
结果表明，与安慰剂相比，瑞波西汀的应用可改善健康参与者的运动学习、注意力过程和工作记忆表现。
因此，本研究的结果表明，去甲肾上腺素能增强作用可改善健康人群的记忆形成和执行功能。相应的变化与去甲肾上腺素对皮质兴奋性和可塑性的相关影响一致。
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