Plewnia Christian, Hoppe Julia, Gerloff Christian
Department of Psychiatry and Psychotherapy, Eberhard-Karls University Medical School, Osianderstrasse 24, Tuebingen 72076, Germany.
Psychopharmacology (Berl). 2006 Aug;187(2):260-5. doi: 10.1007/s00213-006-0420-5. Epub 2006 Jun 10.
When paired with training, substances that increase monoaminergic transmission in the brain support motor and language learning in healthy subjects and in rehabilitation after brain lesions.
To test the hypotheses that enhancement of central norepinephrine by the selective norepinephrine reuptake inhibitor reboxetine (1) improves skilled motor performance, (2) promotes skilled motor learning, and (3) does not exert these effects by modulation of attention.
In a double blind, placebo-controlled, crossover study in healthy, adult subjects (n=16), finger-sequence performance and learning was measured after the stimulation of the central noradrenergic system with a single dose (8 mg) of reboxetine and placebo. Effects on attention were assessed by the standardized continuous performance test "CPT-M".
No differential effects of reboxetine or placebo on finger-sequence performance, learning and parameters of attention were found.
Selective stimulation of the central noradrenergic system did not promote skilled motor learning or performance as assessed by finger-sequences. The plasticity-enhancing effect of reboxetine, documented in other studies, appears to be dependent on specific neurophysiological and neuropsychological characteristics of the task, and cannot be generalized to other behavioral paradigms.
与训练相结合时，能增强大脑单胺能传递的物质可支持健康受试者的运动和语言学习以及脑损伤后的康复。
检验以下假设：选择性去甲肾上腺素再摄取抑制剂瑞波西汀增强中枢去甲肾上腺素能（1）改善熟练运动表现，（2）促进熟练运动学习，以及（3）并非通过调节注意力来发挥这些作用。
在一项针对健康成年受试者（n = 16）的双盲、安慰剂对照、交叉研究中，在单次服用一剂（8毫克）瑞波西汀和安慰剂刺激中枢去甲肾上腺素能系统后，测量手指序列表现和学习情况。通过标准化的连续性能测试“CPT - M”评估对注意力的影响。
未发现瑞波西汀或安慰剂对手指序列表现、学习和注意力参数有差异影响。
如通过手指序列评估，选择性刺激中枢去甲肾上腺素能系统并未促进熟练运动学习或表现。瑞波西汀在其他研究中记录的可塑性增强作用似乎取决于任务的特定神经生理和神经心理特征，且不能推广到其他行为范式。
