Grotowski Maciej
Klinika Chirurgiczna Wojskowego Instytutu Medycyny Lotniczej w Warszawie.
Pol Merkur Lekarski. 2004 Mar;16(93):289-92.
Rectal cancer poses a significant worldwide problem. Until the late 19 century surgeons were convinced that surgical attempts of treating rectal cancers were doomed to failure. Currently, surgery is associated with a poor prognosis, a high likelihood of permanent colostomy and a high rate of local recurrence in patients with regional disease. Functional changes such as bladder dysfunction and impotence remain distressingly common consequences of conventional surgery. An important understanding of rectal cancer pathology allied to modern surgical techniques such as intestinal stapling guns has led to an increased number of sphincter saving operations. The technique of sharp dissection along definable planes known as total mesorectal excision (TME) produces the complete resection of an intact package of the rectum and surrounding mesorectum, enveloped within the visceral pelvic fascia with uninvolved circumferential margins. As a result of TME, 5-year survival figures have risen from 45-50% to 78%, local recurrence rates have declined from 30% to 5-8%, sphincter preservation has risen by at least 20%, and the rates of bladder dysfunction and impotence have declined from 50-70% to 15%. In some selected cases transanal techniques with or without radiotherapy have improved the success of local excision. The value of laparoscopic surgery for rectal cancer in terms of cancer outcome can only be assessed by large clinical trials with sufficient follow-up.
直肠癌是一个全球性的重大问题。直到19世纪末,外科医生一直认为治疗直肠癌的手术尝试注定会失败。目前,手术预后较差,永久性结肠造口的可能性很高,局部疾病患者的局部复发率也很高。膀胱功能障碍和阳痿等功能变化仍然是传统手术令人苦恼的常见后果。对直肠癌病理学的重要认识与诸如肠道吻合器等现代手术技术相结合,使得保留括约肌的手术数量增加。沿着可定义平面进行锐性分离的技术,即全直肠系膜切除术(TME),能够完整切除包裹在盆腔脏层筋膜内、切缘无肿瘤累及的直肠及周围直肠系膜。由于TME,5年生存率从45%-50%提高到了78%,局部复发率从30%下降到了5%-8%,括约肌保留率至少提高了20%,膀胱功能障碍和阳痿的发生率从50%-70%下降到了15%。在一些特定病例中,经肛门技术联合或不联合放疗提高了局部切除的成功率。腹腔镜手术治疗直肠癌在癌症治疗效果方面的价值只能通过有足够随访的大型临床试验来评估。