• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Deactivation of visual transduction without guanosine triphosphate hydrolysis by G protein.

作者信息

Erickson M A, Robinson P, Lisman J

机构信息

Department of Biochemistry, Brandeis University, Waltham, MA 02254.

出版信息

Science. 1992 Aug 28;257(5074):1255-8. doi: 10.1126/science.1519062.

DOI:10.1126/science.1519062
PMID:1519062
Abstract

G proteins couple receptors to their target enzymes in many signal transduction cascades. It has generally been thought that deactivation of such cascades cannot occur without the hydrolysis of guanosine triphosphate (GTP) by G protein. This requirement has now been reexamined in both vertebrate and invertebrate phototransduction. Results indicate that GTP hydrolysis is not required for deactivation. Evidence is presented for an alternative model in which the target enzyme is deactivated by an inhibitory factor that is available even when GTP hydrolysis is blocked.

摘要

相似文献

1
Deactivation of visual transduction without guanosine triphosphate hydrolysis by G protein.
Science. 1992 Aug 28;257(5074):1255-8. doi: 10.1126/science.1519062.
2
Excitation of Limulus photoreceptors by vanadate and by a hydrolysis-resistant analog of guanosine triphosphate.钒酸盐和鸟苷三磷酸的抗水解类似物对鲎光感受器的刺激作用。
Science. 1981 May 1;212(4494):555-7. doi: 10.1126/science.6782676.
3
G-protein deactivation is rate-limiting for shut-off of the phototransduction cascade.G蛋白失活是光转导级联反应关闭的限速步骤。
Nature. 1997 Sep 25;389(6649):392-5. doi: 10.1038/38750.
4
An estimate of the number of G regulator proteins activated per excited rhodopsin in living Limulus ventral photoreceptors.对活体鲎腹侧光感受器中每个受激发的视紫红质激活的G调节蛋白数量的估计。
Proc Natl Acad Sci U S A. 1989 May;86(10):3872-6. doi: 10.1073/pnas.86.10.3872.
5
Mechanisms of amplification, deactivation, and noise reduction in invertebrate photoreceptors.
Soc Gen Physiol Ser. 1992;47:175-99.
6
The molecules of visual excitation.
Sci Am. 1987 Jul;257(1):42-50. doi: 10.1038/scientificamerican0787-42.
7
Mechanism of GTP hydrolysis by G-protein alpha subunits.G蛋白α亚基催化GTP水解的机制。
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9828-31. doi: 10.1073/pnas.91.21.9828.
8
A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs.一种GDP解离抑制剂，可作为Ras样蛋白CDC42Hs的GTP酶抑制剂。
Science. 1992 Oct 30;258(5083):812-5. doi: 10.1126/science.1439791.
9
Excised patches of plasma membrane from vertebrate rod outer segments retain a functional phototransduction enzymatic cascade.从脊椎动物视杆细胞外段切除的质膜片保留了功能性光转导酶促级联反应。
Proc Natl Acad Sci U S A. 1990 Jun;87(11):4226-30. doi: 10.1073/pnas.87.11.4226.
10
Insulin activates guanosine 5'-[gamma-thio] triphosphate (GTP gamma S) binding to a novel GTP-binding protein, GIR, from human placenta.胰岛素可激活鸟苷5'-[γ-硫代]三磷酸（GTPγS）与一种来自人胎盘的新型GTP结合蛋白GIR的结合。
Biochem Biophys Res Commun. 1990 Dec 14;173(2):501-6. doi: 10.1016/s0006-291x(05)80062-2.

引用本文的文献

1
Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 1: identification of its inhibitory subunit complexes and their roles.哺乳动物环鸟苷酸磷酸二酯酶 6.1 的调节机制：其抑制性亚基复合物的鉴定及其作用。
Mol Cell Biochem. 2010 Jun;339(1-2):215-33. doi: 10.1007/s11010-010-0387-8. Epub 2010 Feb 12.
2
GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase.通过环鸟苷酸磷酸二酯酶过量的γ亚基实现光感受器光反应的无GAP依赖性终止。
J Neurosci. 2006 Apr 26;26(17):4472-80. doi: 10.1523/JNEUROSCI.4775-05.2006.
3
The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties.
富含谷氨酸的蛋白2（GARP2）是一种高亲和力的视杆光感受器磷酸二酯酶（PDE6）结合蛋白，可调节其催化特性。
J Biol Chem. 2006 Mar 3;281(9):5500-5. doi: 10.1074/jbc.M507488200. Epub 2006 Jan 3.
4
Is signal transduction modulated by an interaction between heterotrimeric G-proteins and tubulin?异源三聚体G蛋白与微管蛋白之间的相互作用是否调节信号转导？
Endocrine. 1997 Oct;7(2):127-43. doi: 10.1007/BF02778134.
5
Ca2+/calmodulin-binding peptides block phototransduction in Limulus ventral photoreceptors: evidence for direct inhibition of phospholipase C.钙离子/钙调蛋白结合肽阻断鲎腹侧光感受器的光转导：直接抑制磷脂酶C的证据
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14095-9. doi: 10.1073/pnas.94.25.14095.
6
The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro.一种新的视网膜特异性RGS蛋白的核心结构域在体外刺激转导素的GTP酶活性。
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2945-50. doi: 10.1073/pnas.94.7.2945.
7
Effect of bolesatine on phospholipid/calcium dependent protein kinase in Vero cells and in rat thymus.博来霉素对非洲绿猴肾细胞和大鼠胸腺中磷脂/钙依赖性蛋白激酶的作用。
Arch Toxicol. 1995;69(9):624-30. doi: 10.1007/s002040050223.
8
cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction.光感受器磷酸二酯酶上的cGMP结合位点：在视觉转导反馈调节中的作用
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4845-9. doi: 10.1073/pnas.91.11.4845.