[口腔鳞状细胞癌侵袭性肿瘤前沿颈部淋巴结转移与基质金属蛋白酶-2表达的相关性]
[The correlation between neck lymphy node metastasis and matrixmetalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas].
作者信息
Liu Lai-kui, Li Yi-ning, Jiang Hong-bing, He Zhi-xiu, Yi Xin-zhu
机构信息
Dept. of Oral Pathology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2004 Apr;22(2):106-8.
OBJECTIVE
To explore the correlation between neck lymph node metastasis and matrix metalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas(OSCC).
METHODS
Immunohistochemistry LsAB technique was used to observe the expression of MMP-2 at the invasive tumor front and center of OSCC, and the correlation between the expression of MMP-2 in OSCC and neck lymph node metastasis were respectively analyzed by statistics.
RESULTS
The results demonstrated that MMP-2 existed in all 71 cases, which the expression of MMP-2 at the OSCC front was more significant than that of MMP-2 at the OSCC center (P < 0.01), and related to neck lymph node metastasis (P < 0.05).
CONCLUSION
The expression of MMP-2 at the OSCC front could be considered as an index of judging the present of neck lymph node metastasis of OSCC.
目的
探讨口腔鳞状细胞癌（OSCC）侵袭性肿瘤前沿颈部淋巴结转移与基质金属蛋白酶-2表达之间的相关性。
方法
采用免疫组织化学LsAB技术观察基质金属蛋白酶-2在OSCC侵袭性肿瘤前沿及中心的表达情况，并分别对OSCC中基质金属蛋白酶-2的表达与颈部淋巴结转移之间的相关性进行统计学分析。
结果
结果表明，71例病例中均存在基质金属蛋白酶-2，OSCC前沿基质金属蛋白酶-2的表达比OSCC中心更显著（P < 0.01），且与颈部淋巴结转移相关（P < 0.05）。
结论
OSCC前沿基质金属蛋白酶-2的表达可作为判断OSCC颈部淋巴结转移存在情况的指标。
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