Hart S, Horsman J M, Radstone C R, Hancock H, Goepel J R, Hancock B W
YCR Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield, UK.
Clin Oncol (R Coll Radiol). 2004 May;16(3):186-92. doi: 10.1016/j.clon.2003.10.010.
Over the 30-year period from 1971-2000, 3750 cases of lymphoma were referred to the Sheffield Lymphoma Group for investigation and treatment. Of these, 580 were extranodal presentations and, of these, 190 (33%) were localised to the head and neck region. The aim of this lymphoma database review was to evaluate the patient characteristics and survival rates for these patients.
The sample included 98 women and 92 men, with a median age at presentation of 65 years.
The most common site affected was tonsil (34%), followed by salivary glands (16%). Other common sites were the thyroid, orbit and nasopharynx. The most frequent presenting feature was a swelling or mass, with pain, dysphagia and nasal obstruction also comprising large groups. All cases were non-Hodgkin's lymphoma. Fifty-five cases were histological grade 1; 132 were grade 2. Diffuse large B cell was the most common histological subtype. The overall 5- and 10-year survival rates were 55% (95% CI 47-62) and 44%, (95% CI 36-53), respectively, with a median survival of 92 months (95% CI 56-128). Stage and grade were both found to influence survival.
This data concords with and extends information available from previous studies. More detail is now required on specific head and neck sites.
在1971年至2000年的30年期间，3750例淋巴瘤患者被转诊至谢菲尔德淋巴瘤研究组进行调查和治疗。其中，580例为结外表现，其中190例（33%）局限于头颈部区域。本淋巴瘤数据库回顾的目的是评估这些患者的特征和生存率。
样本包括98名女性和92名男性，就诊时的中位年龄为65岁。
最常受累的部位是扁桃体（34%），其次是唾液腺（16%）。其他常见部位是甲状腺、眼眶和鼻咽。最常见的临床表现是肿胀或肿块，疼痛、吞咽困难和鼻塞也占很大比例。所有病例均为非霍奇金淋巴瘤。55例为组织学1级；132例为2级。弥漫性大B细胞是最常见的组织学亚型。总的5年和10年生存率分别为55%（95%CI 47 - 62）和44%（95%CI 36 - 53），中位生存期为92个月（95%CI 56 - 128）。分期和分级均被发现会影响生存率。
这些数据与先前研究的信息一致并有所扩展。现在需要关于特定头颈部部位的更多详细信息。
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