School of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
Int J Environ Res Public Health. 2022 Feb 24;19(5):2605. doi: 10.3390/ijerph19052605.
This study aimed to retrospectively evaluate the incidence of oral non-Hodgkin lymphoma (NHL) in patients referred to the Academic Hospital of the Magna Graecia University of Catanzaro from 2002 to 2020. A retrospective single-center study was performed. Patients with a histologically confirmed diagnosis of oral NHL were included. Demographic data and clinical parameters were digitally recorded, focusing on the NHL-specific localization and symptomatology. The study sample was evaluated by analyzing descriptive statistics with absolute and relative frequencies. A total of 26 patients with intraoral NHL were identified with a progressive increase in NHL occurrence during the observation period. Clinical manifestations included swelling/mass (80.7%), eventually associated with pain and ulcerations. The most common localizations were in soft tissues: buccal mucosa (38.4%), tongue (19.2%), gingiva (11.5%), cheek (11.5%). Oral NHL is rare. Clinical manifestations were unspecific, so a misdiagnosis could occur. The extranodal B-cell form of oral NHL, particularly diffuse large B-cell lymphoma, was the most common frequent oral NHL in this southern Italian population, with a progressively increased occurrence in almost 20 years.
本研究旨在回顾性评估 2002 年至 2020 年期间，来自卡拉布里亚 Magna Graecia 大学学术医院的患者中口腔非霍奇金淋巴瘤（NHL）的发病率。这是一项回顾性单中心研究。纳入经组织学证实为口腔 NHL 的患者。对人口统计学数据和临床参数进行数字化记录，重点关注 NHL 特异性定位和症状。通过分析描述性统计数据（包括绝对频率和相对频率）评估研究样本。本研究共确定了 26 例口腔 NHL 患者，在观察期间 NHL 的发生呈递增趋势。临床表现包括肿胀/肿块（80.7%），最终伴有疼痛和溃疡。最常见的部位是软组织：颊黏膜（38.4%）、舌（19.2%）、牙龈（11.5%）、颊部（11.5%）。口腔 NHL 较为罕见。临床表现无特异性，因此可能导致误诊。在这种意大利南部人群中，口腔 NHL 最常见的形式是非结外 B 细胞型，尤其是弥漫性大 B 细胞淋巴瘤，在近 20 年中，其发病率呈递增趋势。
