Oral Pathology Department, Faculty of Oral and Dental Medicine, Misr International University, Cairo, Egypt.
Oral and Maxillofacial Pathology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
BMC Oral Health. 2022 Dec 1;22(1):556. doi: 10.1186/s12903-022-02582-8.
Little is known about the epidemiology of lymphomas occurring in oral and para-oral sites, especially in developing countries such as Egypt. Hence, the aim of this study was to describe the frequency and time trends of oral and para-oral lymphomas in Cairo governorate from 2010 to 2019, with forecasting to 2030, and to examine relations between age, gender, site and type of lymphoma.
Histopathological reports of patients diagnosed with oral and para-oral lymphomas from 2010 to 2019 were retrospectively retrieved from archives of six different centers in Cairo governorate. Data regarding age, gender and site was collected and associations between types of lymphoma and these variables were detected using appropriate statistical methods. The significance level was set at p ≤ 0.05. Time series analysis was used to determine the trend of lymphoma frequency within 10 years of the study and to predict frequency until 2030.
Lymphomas constituted 2.86% of oral and para-oral lesions. Non-Hodgkin lymphoma was more common than Hodgkin lymphoma. Patients with non-Hodgkin lymphoma showed a higher median age than patients with Hodgkin lymphoma (p = 0.001). Non-Hodgkin lymphoma was more prone to occur intra-orally (p = 0.014). No statistical significance was observed in gender distribution between Hodgkin and non-Hodgkin lymphoma. Even though no specific time trend was observed from 2010 to 2019, forecasting for frequency of lymphomas through 10 years (2020 to 2030) showed a predicted increase.
The findings of this study were consistent with majority of other studies held in various geographic regions. The study revealed that frequency of oral and para-oral lymphomas in Cairo governorate is expected to rise; hence, oral pathologists should be more clinically suspicious and expect to encounter these lesions more in their practice within the upcoming years.
口腔和口咽部位发生的淋巴瘤的流行病学情况鲜为人知，尤其是在埃及等发展中国家。因此，本研究的目的是描述 2010 年至 2019 年开罗省口腔和口咽部位淋巴瘤的发生频率和时间趋势，并预测到 2030 年，同时还研究了年龄、性别、部位和淋巴瘤类型之间的关系。
从开罗省六个不同中心的档案中回顾性检索了 2010 年至 2019 年诊断为口腔和口咽淋巴瘤的患者的组织病理学报告。收集了年龄、性别和部位的数据，并使用适当的统计方法检测了淋巴瘤类型与这些变量之间的关系。显著性水平设为 p≤0.05。时间序列分析用于确定研究 10 年内淋巴瘤频率的趋势，并预测到 2030 年的频率。
淋巴瘤占口腔和口咽病变的 2.86%。非霍奇金淋巴瘤比霍奇金淋巴瘤更常见。非霍奇金淋巴瘤患者的中位年龄高于霍奇金淋巴瘤患者（p=0.001）。非霍奇金淋巴瘤更倾向于发生在口腔内（p=0.014）。霍奇金和非霍奇金淋巴瘤之间的性别分布没有统计学意义。尽管 2010 年至 2019 年期间未观察到特定的时间趋势，但通过 10 年（2020 年至 2030 年）预测淋巴瘤的频率显示出预测的增加。
本研究的结果与在不同地理区域进行的大多数其他研究一致。研究表明，开罗省口腔和口咽部位淋巴瘤的发生频率预计会上升；因此，口腔病理学家在未来几年的临床实践中应该更加怀疑这些病变的存在，并期望更多地遇到这些病变。
