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给伴侣动物口服给药:适口性考量

Oral delivery of medications to companion animals: palatability considerations.

作者信息

Thombre Avinash G

机构信息

Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA.

出版信息

Adv Drug Deliv Rev. 2004 Jun 23;56(10):1399-413. doi: 10.1016/j.addr.2004.02.012.

Abstract

There is an increased need for highly palatable solid oral dosage forms for companion animals, which are voluntarily accepted by the dog or cat, either from a feeding bowl or from the outstretched hand of the pet owner. Such dosage forms represent an emerging trend in companion animal formulations with major impact on medical needs such as convenience and compliance, particularly for chronically administered medications, and on marketing needs such as product differentiation. This review focuses on the science of taste, food and flavor preferences of dogs and cats, and palatability testing, in the context of applying these principles to the development of an oral palatable tablet for companion animals.

摘要

对于伴侣动物而言,对美味的固体口服剂型的需求日益增加,这些剂型能被狗或猫自愿接受,无论是从食碗中还是从宠物主人伸出的手中。此类剂型代表了伴侣动物制剂中的一种新兴趋势,对诸如便利性和顺应性等医疗需求有重大影响,特别是对于长期给药的药物,并且对诸如产品差异化等市场需求也有重大影响。本综述聚焦于狗和猫的味觉、食物及风味偏好科学,以及适口性测试,探讨如何将这些原理应用于开发伴侣动物用口服适口片剂。

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