Tookey P
Paediatric Epidemiology, Institute of Child Health, London, UK.
Euro Surveill. 2004 Apr;9(4):21-3. doi: 10.2807/esm.09.04.00464-en.
Rubella vaccine was offered to schoolgirls in the United Kingdom (UK) from 1970, with antenatal testing and postpartum vaccination for susceptible women introduced during the 1970s. Mass vaccination with MMR of children aged 12-15 months was introduced in 1988; schoolgirl vaccination was discontinued in 1996 and replaced by a second dose of MMR for pre-school children; postpartum vaccination of susceptible women identified through antenatal testing continues. Rubella was made a notifiable disease in 1988, and is monitored through clinical and laboratory reports; data are available on rubella associated terminations and congenital rubella syndrome(CRS) births, rubella susceptibility in population subgroups, and vaccine uptake. Reported cases of CRS declined from about 50 a year 1971-75 to just over 20 a year 1986-90, and rubella associated terminations from an average of 750 to 50 a year. About 40 infants with CRS have been reported since 1991; about a third of their mothers were infected abroad, most in their country of origin (imported infections), a third were born abroad but acquired infection in the UK, and a third were UK-born. Women living in the UK who were born abroad have much higher rubella susceptibility rates than UK-born women. Although there is currently very little rubella infection circulating, uptake of MMR has dropped by over 10% since 1995. If rubella starts to circulate again, immigrant women will be at increased risk of acquiring infection in pregnancy.
1970年起,英国开始为女学生接种风疹疫苗,20世纪70年代引入了针对易感女性的产前检测和产后疫苗接种。1988年开始对12至15个月大的儿童进行麻疹、腮腺炎和风疹(MMR)三联疫苗大规模接种;1996年停止了女学生接种,取而代之的是为学龄前儿童接种第二剂MMR;通过产前检测确定的易感女性的产后疫苗接种仍在继续。风疹于1988年被列为须上报的疾病,并通过临床和实验室报告进行监测;现有关于风疹相关终止妊娠和先天性风疹综合征(CRS)出生病例、人群亚组中风疹易感性以及疫苗接种情况的数据。报告的CRS病例从1971 - 1975年每年约50例下降到1986 - 1990年每年略超过20例,风疹相关终止妊娠从平均每年750例降至每年50例。自1991年以来,已报告约40例CRS婴儿;其中约三分之一的母亲在国外感染,大多数在其原籍国(输入性感染),三分之一在国外出生但在英国感染,三分之一是在英国出生。在英国生活的外国出生女性的风疹易感性率比英国出生女性高得多。尽管目前风疹感染传播极少,但自1995年以来,MMR疫苗接种率下降了超过10%。如果风疹再次开始传播,移民女性在孕期感染的风险将增加。