Mirambo Mariam M, Majigo Mtebe, Scana Seth D, Mushi Martha F, Aboud Said, Groß Uwe, Kidenya Benson R, Mshana Stephen E
Department of Microbiology and Immunology, Weill Bugando School of medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Department of Microbiology and Immunology, Muhimbili university of Health and allied sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
BMC Womens Health. 2018 Jan 3;18(1):3. doi: 10.1186/s12905-017-0505-9.
Rubella primary infection during early stages of pregnancy is associated with high risk of congenital Rubella syndrome (CRS). Prevention of CRS in the resource-limited countries requires multiple strategies. Here, we document the data on the magnitude of Rubella natural immunity among adolescent girls which is a crucial group in devising effective control strategies to prevent CRS.
A cross sectional study involving 397 adolescent girls was conducted in the city of Mwanza involving five secondary schools. Socio-demographic and other relevant information were collected using pre-tested data collection tool. Rubella IgG antibodies were determined using enzyme immunoassay. The presence of Rubella IgG titers of >10 IU/ml indicated natural immunity.
The mean age of the study participants was 15.18 ± 1.48 years. Of 397 girls, 340 (85.6%) and 57 (14.4%) were from secondary schools representing peri-urban and rural areas, respectively. Out of 397 girls, 90.4% (95% CI: 87-93) were found to be naturally immune with median Rubella IgG antibodies titers of 56.7 IU/ml interquartile range (IQR): 40.8-137. The median Rubella IgG antibodies titers were significantly high in adolescent girls from families with high socio-economic status (63.96 vs. 47.13 IU/ml, P < 0.001) and in adolescent girls from peri-urban areas of the city (63.33 vs. 39.9 IU/ml, P < 0.001).
The majority of adolescent girls in the city of Mwanza are naturally immune to Rubella virus. There is a need to compare the effectiveness of screening and vaccinating susceptible adolescent girls with the effectiveness of vaccinating all women of childbearing in controlling CRS in low-income countries.
孕期早期的风疹原发性感染与先天性风疹综合征（CRS）的高风险相关。在资源有限的国家预防CRS需要多种策略。在此，我们记录了青春期女孩中风疹自然免疫程度的数据，这是制定预防CRS有效控制策略的关键群体。
在姆万扎市对五所中学的397名青春期女孩进行了一项横断面研究。使用预先测试的数据收集工具收集社会人口统计学和其他相关信息。采用酶免疫测定法测定风疹IgG抗体。风疹IgG滴度>10 IU/ml表明具有自然免疫力。
研究参与者的平均年龄为15.18±1.48岁。在397名女孩中，340名（85.6%）和57名（14.4%）分别来自代表城郊和农村地区的中学。在397名女孩中，90.4%（95%CI：87-93）被发现具有自然免疫力，风疹IgG抗体滴度中位数为56.7 IU/ml，四分位间距（IQR）：40.8-137。社会经济地位高的家庭中的青春期女孩（63.96对47.13 IU/ml，P<0.001）以及该市城郊地区的青春期女孩（63.33对39.9 IU/ml，P<0.001）的风疹IgG抗体滴度中位数显著较高。
姆万扎市的大多数青春期女孩对风疹病毒具有自然免疫力。有必要比较筛查和接种易感青春期女孩与接种所有育龄妇女在低收入国家控制CRS方面的有效性。
