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精索静脉曲张栓塞术对不育治疗选择的影响。

Influence of varicocele embolization on the choice of infertility treatment.

作者信息

Tanahatoe Sandra J, Maas Willemijn M, Hompes Peter G A, Lambalk Cornelis B

机构信息

Vrije Universiteit Medical Centre, Amsterdam, The Netherlands.

出版信息

Fertil Steril. 2004 Jun;81(6):1679-83. doi: 10.1016/j.fertnstert.2003.10.044.

Abstract

OBJECTIVE

To investigate whether embolization of a varicocele improves semen quality and enables use of less-invasive modes of assisted reproductive technology (ART) in infertile men with a physically palpable varicocele confirmed by phlebography.

DESIGN

Retrospective chart review.

SETTING

University infertility clinic.

PATIENT(S): Fifty patients with varicoceles that were treated with embolization and 11 patients with untreated varicoceles (control group). In both groups the clinical varicoceles had been phlebographically confirmed.

INTERVENTION(S): Phlebography and embolization.

MAIN OUTCOME MEASURE(S): Semen characteristics and mode of ART before and after treatment.

RESULT(S): Median improvements of semen parameters, such as concentration and motility after processing, were significantly greater in the embolization group than in the untreated group. In the embolization group, semen samples improved to levels requiring less-invasive modes of ART in significantly more patients than in the untreated group. Deterioration of semen samples, requiring more invasive techniques, was significantly more frequent in the untreated group than in the embolization group.

CONCLUSION(S): Embolization of a varicocele in infertile men significantly improved semen, such that much more often a less-invasive form of ART than was planned before treatment became feasible. Embolization of a varicocele might even prevent further deterioration of semen samples to levels requiring more-invasive ART.

摘要

目的

探讨精索静脉曲张栓塞术是否能改善精液质量,并使经静脉造影证实存在可触及精索静脉曲张的不育男性能够采用侵入性较小的辅助生殖技术(ART)模式。

设计

回顾性病历审查。

地点

大学不育门诊。

患者

50例接受精索静脉曲张栓塞治疗的患者和11例未治疗精索静脉曲张的患者(对照组)。两组患者的临床精索静脉曲张均经静脉造影证实。

干预措施

静脉造影和栓塞术。

主要观察指标

治疗前后的精液特征和ART模式。

结果

栓塞组精液参数(如处理后的浓度和活力)的中位数改善明显大于未治疗组。在栓塞组中,精液样本改善到需要侵入性较小的ART模式水平的患者明显多于未治疗组。需要更侵入性技术的精液样本恶化在未治疗组中比栓塞组明显更频繁。

结论

不育男性精索静脉曲张栓塞术显著改善了精液质量,使得比治疗前计划的更常采用侵入性较小的ART形式变得可行。精索静脉曲张栓塞术甚至可能防止精液样本进一步恶化到需要更侵入性ART的水平。

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