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患者的家族史对高血压具有敏感性,对糖尿病具有特异性。

Patients' sibling history was sensitive for hypertension and specific for diabetes.

作者信息

Bochud Murielle, Burnier Michel, Paccaud Fred, Falconnet Catherine, Mooser Vincent, Both Norma, Bovet Pascal

机构信息

University Institute for Social and Preventive Medicine, Rue du Bugnon 17, 1005 Lausanne, Switzerland.

出版信息

J Clin Epidemiol. 2004 May;57(5):497-501. doi: 10.1016/j.jclinepi.2003.10.008.

Abstract

OBJECTIVE

We examined the analytic validity of reported family history of hypertension and diabetes among siblings in the Seychelles.

STUDY DESIGN AND SETTING

Four hundred four siblings from 73 families with at least two hypertensive persons were identified through a national hypertension register. Two gold standards were used prospectively. Sensitivity was the proportion of respondents who indicated the presence of disease in a sibling, given that the sibling reported to be affected (personal history gold standard) or was clinically affected (clinical status gold standard). Specificity was the proportion of respondents who reported an unaffected sibling, given that the sibling reported to be unaffected or was clinically unaffected. Respondents gave information on the disease status in their siblings in approximately two-thirds of instances.

RESULTS

When sibling history could be obtained (n=348 for hypertension, n=404 for diabetes), the sensitivity and the specificity of the sibling history were, respectively, 90 and 55% for hypertension, and 61 and 98% for diabetes, using clinical status and, respectively, 89 and 78% for hypertension, and 53 and 98% for diabetes, using personal history.

CONCLUSION

The sibling history, when available, is a useful screening test to detect hypertension, but it is less useful to detect diabetes.

摘要

目的

我们研究了塞舌尔群岛兄弟姐妹中报告的高血压和糖尿病家族史的分析效度。

研究设计与背景

通过国家高血压登记册,从73个至少有两名高血压患者的家庭中识别出404名兄弟姐妹。前瞻性地使用了两个金标准。敏感性是指在兄弟姐妹报告患病(个人病史金标准)或临床确诊患病(临床状态金标准)的情况下,指出兄弟姐妹患有疾病的受访者比例。特异性是指在兄弟姐妹报告未患病或临床未患病的情况下,报告兄弟姐妹未患病的受访者比例。约三分之二的受访者提供了其兄弟姐妹的疾病状况信息。

结果

当能够获取兄弟姐妹的病史时(高血压n = 348,糖尿病n = 404),使用临床状态时,高血压的兄弟姐妹病史敏感性和特异性分别为90%和55%,糖尿病分别为61%和98%;使用个人病史时,高血压分别为89%和78%,糖尿病分别为53%和98%。

结论

如有兄弟姐妹病史,它是检测高血压的一项有用筛查测试,但对检测糖尿病的作用较小。

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