Choi Jay Chol, Lee Jung Seok, Kang Sa-Yoon, Kang Ji-Hoon, Bae Jong-Myon
Department of Neurology and Institute of Medical Science, Jeju National University, Jeju, Republic of Korea.
J Neurol Sci. 2009 Sep 15;284(1-2):29-32. doi: 10.1016/j.jns.2009.03.015. Epub 2009 Apr 16.
Current data concerning the association between family history and the risk for developing stroke have been controversial. There has been very little data on the influence of family history on intracranial atherosclerosis (ICAS), stroke severity, and recovery, especially among Asian populations. We evaluated the association between family history and the risk for stroke and investigated the relationships between family history and ICAS, stroke severity, and short-term stroke outcome in Korean stroke patients. In this case-control study, we recruited 400 patients with acute ischemic stroke, along with the same number of age- and gender-matched control subjects. Assessments of first-degree family history of stroke, myocardial infarction, hypertension and diabetes mellitus were obtained by structured questionnaires, followed by reviews of the clinical and neuro-radiological findings of the stroke patients. A family history of stroke was associated with an increased risk of ischemic stroke (OR, 2.65; 95% CI, 1.75 to 4.01), and the correlation remained significant after multivariate analysis. The odds ratios of paternal, maternal, and sibling history were 2.07, 2.16, and 4.21, respectively. The risk of stroke did not differ significantly with the presence of ICAS, stroke severity, and stroke outcome. Family history of stroke was an independent risk factor for ischemic stroke. A positive sibling history was more strongly correlated with the incidence of stroke than a positive parental history, and this finding may indicate the possible role of environmental factors in a shared household in addition to the genetic factors involved in family medical history.
目前关于家族病史与中风发病风险之间关联的数据存在争议。关于家族病史对颅内动脉粥样硬化（ICAS）、中风严重程度及恢复情况的影响，相关数据极少，尤其是在亚洲人群中。我们评估了家族病史与中风风险之间的关联，并调查了韩国中风患者中家族病史与ICAS、中风严重程度及短期中风预后之间的关系。在这项病例对照研究中，我们招募了400例急性缺血性中风患者以及相同数量的年龄和性别匹配的对照受试者。通过结构化问卷获取中风、心肌梗死、高血压和糖尿病的一级家族病史评估信息，随后对中风患者的临床和神经放射学检查结果进行回顾。中风家族病史与缺血性中风风险增加相关（比值比，2.65；95%可信区间，1.75至4.01），多因素分析后该相关性仍显著。父亲、母亲和兄弟姐妹有家族病史的比值比分别为2.07、2.16和4.21。中风风险在是否存在ICAS、中风严重程度及中风预后方面无显著差异。中风家族病史是缺血性中风的独立危险因素。兄弟姐妹有家族病史比父母有家族病史与中风发病率的相关性更强，这一发现可能表明除家族病史中的遗传因素外，共同家庭环境因素也可能发挥作用。
