Department of Public Health, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands.
J Clin Epidemiol. 2012 Jan;65(1):82-9. doi: 10.1016/j.jclinepi.2011.05.003. Epub 2011 Sep 1.
We investigated the accuracy of self-reported family history for diabetes, hypertension, and overweight against two reference standards: family history based on physician-assessed health status of relatives and on self-reported personal health status of relatives.
Subjects were participants from the Erasmus Rucphen Family study, an extended family study among descendants of 20 couples who lived between 1850 and 1900 in a southwest region of the Netherlands and their relatives (n=1,713). Sensitivity and specificity of self-reported family history were calculated.
Sensitivity of self-reported family history was 89.2% for diabetes, 92.2% for hypertension, and 78.4% for overweight when family history based on relatives' self-reported personal health status was used as reference and 70.8% for diabetes, 67.4% for hypertension, and 77.3% for overweight when physician-assessed health status of relatives was used. Sensitivity and specificity of self-reported personal health status were 76.8% and 98.8% for diabetes, 38.9% and 98.0% for hypertension, and 80.9% and 75.7% for overweight, respectively.
The accuracy of self-reported family history of diabetes and hypertension is strongly influenced by the accuracy of self-reported personal health status of relatives. Raising awareness of personal health status is crucial to ensure the utility of family history for the assessment of risk and disease prevention.
我们调查了自我报告的糖尿病、高血压和超重家族史与两个参考标准的准确性：基于医生评估的亲属健康状况和基于亲属自我报告的个人健康状况的家族史。
研究对象来自于伊拉斯谟鲁琛家庭研究，这是一项在荷兰西南部居住的 20 对夫妇的后代及其亲属（n=1713）的扩展家族研究。计算了自我报告家族史的敏感性和特异性。
当以亲属自我报告的个人健康状况为参考时，自我报告家族史的敏感性为糖尿病 89.2%、高血压 92.2%和超重 78.4%，而当以医生评估的亲属健康状况为参考时，自我报告家族史的敏感性为糖尿病 70.8%、高血压 67.4%和超重 77.3%。自我报告的个人健康状况的敏感性和特异性分别为糖尿病 76.8%和 98.8%、高血压 38.9%和 98.0%以及超重 80.9%和 75.7%。
自我报告的糖尿病和高血压家族史的准确性受到亲属自我报告的个人健康状况准确性的强烈影响。提高对个人健康状况的认识对于确保家族史在评估风险和疾病预防方面的实用性至关重要。
