Horejsi R, Möller R, Rackl S, Giuliani A, Freytag U, Crailsheim K, Sudi K, Tafeit E
Institute for Medical Chemistry and Pregl Laboratory, Karl-Franzens University, A-8010 Graz, Austria.
Am J Phys Anthropol. 2004 Jul;124(3):275-81. doi: 10.1002/ajpa.10364.
The new optical device, the lipometer, enables the noninvasive, quick, safe, and precise determination of the thickness of subcutaneous adipose tissue (SAT) layers at any given site of the human body. Fifteen anatomically well-defined body sites from neck to calf describe a SAT topography (SAT-Top) like an individual "fingerprint" of a subject. This SAT-Top was examined in 16 women with polycystic ovary syndrome (PCOS) and compared to the body fat distribution of 87 age-matched healthy controls and 20 type-2 diabetic women. SAT-Top differences of these three groups were described and, to render the possibility of visual comparison, the 15-dimensional body fat information was condensed to a two-dimensional factor plot by factor analysis. All PCOS patients had an android body fat distribution with significantly thinner SAT layers on the legs as compared to healthy controls. Moreover, a hierarchical cluster analysis resulted in two distinctly different groups of PCOS women, a lean (PCOSL) and an obese (PCOSO) cluster: compared to healthy women, lean PCOS patients had significantly lower total SAT development, even though height, weight, and body mass index did not deviate significantly. Especially on the legs, their SAT layers were significantly lowered, indicating a more "apple-like" fat distribution type. Obese PCOS women showed a SAT-Top pattern very similar to that of women with type-2 diabetes, although the mean age difference between these groups was more than 30 years. Compared to healthy controls, the SAT-Top of these obese PCOS patients was strongly shifted into the android direction, appearing as "super-apples" with a significantly increased upper trunk obesity to 237.8% and a significantly decreased leg SAT development to 79.8%.
新型光学设备——脂肪厚度测量仪，能够在人体任何给定部位对皮下脂肪组织（SAT）层厚度进行无创、快速、安全且精确的测定。从颈部到小腿的15个解剖学上明确界定的身体部位描绘出一种SAT地形（SAT-Top），就像个体的“指纹”。对16名多囊卵巢综合征（PCOS）女性的这种SAT-Top进行了检查，并与87名年龄匹配的健康对照者以及20名2型糖尿病女性的身体脂肪分布进行了比较。描述了这三组的SAT-Top差异，并且为了便于视觉比较，通过因子分析将15维的身体脂肪信息浓缩为二维因子图。所有PCOS患者的身体脂肪分布呈男性化，与健康对照者相比，腿部的SAT层明显更薄。此外，层次聚类分析产生了两组明显不同的PCOS女性，即瘦型（PCOSL）和肥胖型（PCOSO）聚类：与健康女性相比，瘦型PCOS患者的总SAT发育明显更低，尽管身高、体重和体重指数没有显著差异。特别是在腿部，她们的SAT层明显更低，表明脂肪分布类型更像“苹果型”。肥胖型PCOS女性的SAT-Top模式与2型糖尿病女性非常相似，尽管这两组之间的平均年龄差异超过30岁。与健康对照者相比，这些肥胖型PCOS患者的SAT-Top强烈向男性化方向偏移，表现为“超级苹果型”，上躯干肥胖显著增加至237.8%，腿部SAT发育显著降低至79.8%。
