Suppr
超能文献

使用菜豆凝集素反应性甲胎蛋白比率进行产前21三体筛查。

Prenatal trisomy 21 screening using the Lens culinaris agglutinin-reactive alpha-fetoprotein ratio.

作者信息

Yamamoto Ritsu, Minobe Shinichiro, Ebina Yasuhiko, Watari Hidemichi, Kudo Masataka, Henmi Fumiyo, Satomura Shinji, Fujimoto Seiichiro, Minakami Hisanori, Sakuragi Noriaki

机构信息

Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-Ku, Sapporo, Japan.

出版信息

Congenit Anom (Kyoto). 2004 Jun;44(2):87-92. doi: 10.1111/j.1741-4520.2004.00013.x.

DOI:10.1111/j.1741-4520.2004.00013.x

PMID:15198721

Abstract

For the purpose of improving the clinical efficacy of alpha-fetoprotein (AFP)-L3% in prenatal screening for trisomy 21, we calculated the multiple of the median (MoM) of AFP-L3% (L3 MoM) and the ratio of L3 MoM to AFP MoM (L3 MoM/AFP MoM) in maternal serum. Maternal serum samples from 1822 women (maternal age 37.3 +/- 3.8 years, and weeks of gestation 16.0 +/- 1.0; mean +/- SD) with unaffected pregnancies and 28 women (37.6 +/- 4.6 years, 16.6 +/- 3.1) pregnant with of trisomy 21 fetuses were obtained. The AFP concentration and AFP-L3% in maternal serum were measured using a liquid-phase binding assay. The areas under the receiver operating characteristic curves (AUCs) of AFP MoM, AFP-L3%, L3 MoM, and L3 MoM/AFP MoM were 0.750, 0.868, 0.949 and 0.946, respectively. The AUCs of L3 MoM and L3 MoM/AFP MoM were significantly higher than AFP-L3% (P < 0.05) and AFP MoM (P < 0.0005). However, no statistical difference was observed between the AUCs of L3 MoM and L3 MoM/AFP MoM. In conclusion, the L3 MoM should be an effective replacement for AFP-L3% in prenatal trisomy 21 screening.

摘要

为提高甲胎蛋白-L3%（AFP-L3%）在21三体综合征产前筛查中的临床效能，我们计算了孕妇血清中AFP-L3%的中位数倍数（L3 MoM）以及L3 MoM与AFP MoM的比值（L3 MoM/AFP MoM）。收集了1822名未受影响妊娠女性（母亲年龄37.3±3.8岁，孕周16.0±1.0周；均值±标准差）和28名怀有21三体胎儿的孕妇（37.6±4.6岁，16.6±3.1周）的母血清样本。采用液相结合法检测母血清中的AFP浓度和AFP-L3%。AFP MoM、AFP-L3%、L3 MoM和L3 MoM/AFP MoM的受试者操作特征曲线下面积（AUC）分别为0.750、0.868、0.949和0.946。L3 MoM和L3 MoM/AFP MoM的AUC显著高于AFP-L3%（P<0.05）和AFP MoM（P<0.0005）。然而，L3 MoM和L3 MoM/AFP MoM的AUC之间未观察到统计学差异。总之，在产前21三体综合征筛查中，L3 MoM应可有效替代AFP-L3%。