Shintaku Y, Takabayashi T, Sasaki H, Ozawa N, Shinkawa O, Hamazaki Y, Yajima A
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Feb;41(2):185-90.
Between July 1, 1986 and January 31, 1988, genetic amniocentesis was performed on 205 patients. The maternal serum alpha-fetoprotein (AFP) and amniotic fluid AFP levels were measured by enzyme immunoassay. Gestational dates were confirmed by sonography, and AFP results were expressed as multiples of the median (MOM). The median of maternal serum AFP from 15 to 17 weeks of gestation was 43.4, 62.6 and 72.5 ng/ml. Three fetuses with chromosomal anomalies were diagnosed; trisomy 21, 4p trisomy, and trisomy 18 (trisomy 18 was in one fetus of a twin pregnancy; the other fetus was normal). Maternal serum AFP levels were, 0.41, 0.49 and 1.30 MOM. Maternal serum AFP less than 0.5 MOM in normal pregnancies was 1/205 (0.5%) and less than 0.6 MOM was 9/205 (4.4%). There was no relationship between maternal serum AFP and amniotic fluid AFP levels. Our results are in agreement with the majority of the results in the literature, showing that maternal serum AFP levels are lower in association with autosomal trisomy fetuses.
1986年7月1日至1988年1月31日期间，对205名患者进行了基因羊膜穿刺术。采用酶免疫测定法测量母血清甲胎蛋白（AFP）和羊水AFP水平。通过超声检查确定孕周，AFP结果以中位数倍数（MOM）表示。孕15至17周母血清AFP的中位数分别为43.4、62.6和72.5 ng/ml。诊断出3例染色体异常胎儿；21三体、4p三体和18三体（18三体存在于双胎妊娠的1个胎儿中，另1个胎儿正常）。母血清AFP水平分别为0.41、0.49和1.30 MOM。正常妊娠中母血清AFP低于0.5 MOM的比例为1/205（0.5%），低于0.6 MOM的比例为9/205（4.4%）。母血清AFP与羊水AFP水平之间无相关性。我们的结果与文献中的大多数结果一致，表明常染色体三体胎儿的母血清AFP水平较低。
