Guibaud S, Boisson C, Simplot A, Thoulon J M, Favier J P, Guibaud P, Robert J M
Laboratoire de Biochimie, Hôpital de la Croix-Rousse, Lyon.
J Genet Hum. 1988 Aug;36(4):347-51.
In 31 affected pregnancies with Down syndrome, the median maternal serum alpha-fetoprotein value was lower than normal, 0.76 MoM, and median amniotic fluid value was quite normal, 0.98 MoM. Selecting an arbitrary cutoff-point of 0.5 MoM, 4.1 percent of normal gestations show values less than 0.5 MoM. Authors discuss problems about screening for fetal Down's syndrome by measuring maternal serum AFP levels.
在31例患有唐氏综合征的受影响妊娠中，孕妇血清甲胎蛋白值中位数低于正常水平，为0.76倍中位数倍数（MoM），而羊水值中位数相当正常，为0.98 MoM。选择0.5 MoM作为任意临界值，4.1%的正常妊娠显示值低于0.5 MoM。作者讨论了通过测量孕妇血清甲胎蛋白水平筛查胎儿唐氏综合征的相关问题。
